10代の頃の知り合いジョンから突然呼び出されたプレンティスは、共通の友人であるマシューの死を知る。マシューの死は表向きは心筋梗塞で処理されているが、マシューは誰かに殺されると言っていたらしい。そして既に「トミーV」という男が殺されたと。間もなく「トーマス・ヴァレンタイン」という男が脱水症で亡くなっていることがわかる。連続事件の証拠は何もないが、ホッチはプレンティスにこの件について調べることを許可する。
「悪を罰しないものは悪を行えと言っているのだ」
-レオナルド・ダ・ヴィンチ (ルネサンス期を代表する芸術家で、万能の天才)
ゲスト:ブルース・デイヴィソン『X-メン』、ロクサンヌ・ハート「シカゴ・ホープ」、ジェイムズ・レマー「SEX AND THE CITY」
脚本:クリス・マンディ
監督:エドワード・アレン・バーネロ
♪"The Fix" - The Noises 10 / "My Side of the Story" - Hodges
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